KEGG   Homo sapiens (human): 85366
Entry
85366             CDS       T01001                                 
Symbol
MYLK2, KMLC, MLCK, MLCK2, skMLCK
Name
(RefSeq) myosin light chain kinase 2
  KO
K00907  myosin-light-chain kinase [EC:2.7.11.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04611  Platelet activation
hsa04810  Regulation of actin cytoskeleton
hsa04921  Oxytocin signaling pathway
hsa04971  Gastric acid secretion
Network
nt06528  Calcium signaling
  Element
N01648  Ca2+/CAM-CAMK signaling pathway
Disease
H00292  Hypertrophic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    85366 (MYLK2)
   04020 Calcium signaling pathway
    85366 (MYLK2)
   04022 cGMP-PKG signaling pathway
    85366 (MYLK2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    85366 (MYLK2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    85366 (MYLK2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    85366 (MYLK2)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    85366 (MYLK2)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    85366 (MYLK2)
  09154 Digestive system
   04971 Gastric acid secretion
    85366 (MYLK2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    85366 (MYLK2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     85366 (MYLK2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   85366 (MYLK2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Kdo APH DUF6428
Other DBs
NCBI-GeneID: 85366
NCBI-ProteinID: NP_149109
OMIM: 606566
HGNC: 16243
Ensembl: ENSG00000101306
UniProt: Q9H1R3
Structure
Position
20:31819356..31834684
AA seq 596 aa
MATENGAVELGIQNPSTDKAPKGPTGERPLAAGKDPGPPDPKKAPDPPTLKKDAKAPASE
KGDGTLAQPSTSSQGPKGEGDRGGGPAEGSAGPPAALPQQTATPETSVKKPKAEQGASGS
QDPGKPRVGKKAAEGQAAARRGSPAFLHSPSCPAIISSSEKLLAKKPPSEASELTFEGVP
MTHSPTDPRPAKAEEGKNILAESQKEVGEKTPGQAGQAKMQGDTSRGIEFQAVPSEKSEV
GQALCLTAREEDCFQILDDCPPPPAPFPHRMVELRTGNVSSEFSMNSKEALGGGKFGAVC
TCMEKATGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYAAIETPHEIVLFME
YIEGGELFERIVDEDYHLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGH
LVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSMGVITYMLLSGLS
PFLGDDDTETLNNVLSGNWYFDEETFEAVSDEAKDFVSNLIVKDQRARMNAAQCLAHPWL
NNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
NT seq 1791 nt   +upstreamnt  +downstreamnt
atggcgacagaaaatggagcagttgagctgggaattcagaacccatcaacagacaaggca
cctaaaggtcccacaggtgaaagacccctggctgcagggaaagaccctggccccccagac
ccaaagaaagctccggatccacccaccctgaagaaagatgccaaagcccctgcctcagag
aaaggggatggtaccctggcccaaccctcaactagcagccaaggccccaaaggagagggt
gacaggggcggggggcccgcggagggcagtgctgggcccccggcagccctgccccagcag
actgcgacacctgagaccagcgtcaagaagcccaaggctgagcagggagcctcaggcagc
caggatcctggaaagcccagggtgggcaagaaggcagcagagggccaagcagcagccagg
aggggctcacctgcctttctgcatagccccagctgtcctgccatcatctccagttctgag
aagctgctggccaagaagcccccaagcgaggcatcagagctcacctttgaaggggtgccc
atgacccacagccccacggatcccaggccagccaaggcagaagaaggaaagaacatcctg
gcagagagccagaaggaagtgggagagaaaaccccaggccaggctggccaggctaagatg
caaggggacacctcgagggggattgagttccaggctgttccctcagagaaatccgaggtg
gggcaggccctctgtctcacagccagggaggaggactgcttccagattttggatgattgc
ccgccacctccggcccccttccctcaccgcatggtggagctgaggaccgggaatgtcagc
agtgaattcagtatgaactccaaggaggcgctcggaggtggcaagtttggggcagtctgt
acctgcatggagaaagccacaggcctcaagctggcagccaaggtcatcaagaaacagact
cccaaagacaaggaaatggtgttgctggagattgaggtcatgaaccagctgaaccaccgc
aatctgatccagctgtatgcagccatcgagactccgcatgagatcgtcctgttcatggag
tacatcgagggcggagagctcttcgagaggattgtggatgaggactaccatctgaccgag
gtggacaccatggtgtttgtcaggcagatctgtgacgggatcctcttcatgcacaagatg
agggttttgcacctggacctcaagccagagaacatcctgtgtgtcaacaccaccgggcat
ttggtgaagatcattgactttggcctggcacggaggtataaccccaacgagaagctgaag
gtgaactttgggaccccagagttcctgtcacctgaggtggtgaattatgaccaaatctcc
gataagacagacatgtggagtatgggggtgatcacctacatgctgctgagcggcctctcc
cccttcctgggagatgatgacacagagaccctaaacaacgttctatctggcaactggtac
tttgatgaagagacctttgaggccgtatcagacgaggccaaagactttgtctccaacctc
atcgtcaaggaccagagggcccggatgaacgctgcccagtgtctcgcccatccctggctc
aacaacctggcggagaaagccaaacgctgtaaccgacgccttaagtcccagatcttgctt
aagaaatacctcatgaagaggcgctggaagaaaaacttcattgctgtcagcgctgccaac
cgcttcaagaagatcagcagctcgggggcactgatggctctgggggtctga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (60)   

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